Which of the following are signs of an anaphylactic reaction?

Anaphylactic reactions are severe and life-threatening allergic responses that require immediate medical attention. The presence of signs such as difficulty breathing, swelling of the face or tongue, rapid heartbeat, and rashes indicates a systemic reaction affecting multiple body systems.

Difficulty breathing can occur due to bronchoconstriction or swelling in the airways, which makes it hard to inhale. Swelling of the face and tongue is indicative of angioedema, which can obstruct the airways and result in choking. A rapid heartbeat is a sign of the body trying to compensate for decreased oxygen levels or a drop in blood pressure, while rashes or hives are skin manifestations that often accompany allergic reactions.

These symptoms collectively highlight the urgency of an anaphylactic reaction, which necessitates immediate intervention with epinephrine and advanced medical care, making this the correct answer. The other symptoms listed in the other options, while they can be associated with various conditions, do not reflect the classic presentation of anaphylaxis.